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Assoc. Prof. Dr. Souwalak Phongpaichit
Natural Products Research Center, Department of Microbiology, Mangosteen Research and Development Center,
Asian Phytoceuticals Public Co., Ltd.
Wilawan Mahabusarakam
Natural Products Research Center, Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
Metta Ongsakul
Department of Microbiology, Mangosteen Research and Development Center, Asian Phytoceuticals Public Co., Ltd.
โสภา คำมี
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand. |
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World health problems caused by drug-resistant bacteria are increasing. Methicillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen causing hospital and community acquired infections. MRSA infections are more difficult to treat due to the antibiotic-resistance of the bacteria. GM-1 and GM-3, major xanthones from mangosteen (Garcinia mangostana) exhibited antibacterial activity against MRSA comparable to a standard drug vancomycin. Mangosteen xanthone cream can effectively treat skin infection as compared with commercial antibiotics. In addition, these xanthones inhibited the growth of Enterococcus sp.
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